Hirohisa Takano Selected Research

Sand

7/2017	Environmental pollution and allergies.
1/2017	Biological factor related to Asian sand dust particles contributes to the exacerbation of asthma.
4/2016	Differences in allergic inflammatory responses between urban PM2.5 and fine particle derived from desert-dust in murine lungs.
4/2016	Desert dust induces TLR signaling to trigger Th2-dominant lung allergic inflammation via a MyD88-dependent signaling pathway.
1/2016	Co-exposure to zymosan A and heat-inactivated Asian sand dust exacerbates ovalbumin-induced murine lung eosinophilia.
1/2015	Pathological study of chronic pulmonary toxicity induced by intratracheally instilled Asian sand dust (Kosa): possible association of fibrosis with the development of granulomatous lesions.
2/2014	Lung inflammation by fungus, Bjerkandera adusta isolated from Asian sand dust (ASD) aerosol and enhancement of ovalbumin-induced lung eosinophilia by ASD and the fungus in mice.
1/2014	Enhancement of OVA-induced murine lung eosinophilia by co-exposure to contamination levels of LPS in Asian sand dust and heated dust.
11/2013	Ultrastructural changes in the air-blood barrier in mice after intratracheal instillations of Asian sand dust and gold nanoparticles.
11/2013	Effects of two Asian sand dusts transported from the dust source regions of Inner Mongolia and northeast China on murine lung eosinophilia.

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Hirohisa Takano Research Topics

Disease

69	Inflammation (Inflammations) 12/2021 - 01/2002
39	Pneumonia (Pneumonitis) 12/2021 - 05/2002
38	Asthma (Bronchial Asthma) 01/2022 - 01/2002
17	Eosinophilia 01/2017 - 01/2008
13	Acute Lung Injury 04/2010 - 12/2002
12	Lung Injury 11/2013 - 04/2002
10	Respiratory Tract Diseases (Respiratory Tract Disease) 01/2022 - 04/2002
10	Atopic Dermatitis (Atopic Eczema) 12/2021 - 08/2006
10	Hypersensitivity (Allergy) 10/2021 - 11/2005
7	Body Weight (Weight, Body) 01/2019 - 04/2004
6	Pancreatitis 04/2010 - 03/2005
6	Shock 04/2010 - 03/2005
6	Disseminated Intravascular Coagulation 04/2010 - 03/2005
5	Infections 01/2021 - 10/2004
5	Obesity 01/2019 - 10/2003
5	Respiratory Hypersensitivity 01/2019 - 12/2002
5	Lung Diseases (Lung Disease) 02/2014 - 04/2003
4	Allergic Rhinitis 11/2018 - 09/2007
4	Edema (Dropsy) 02/2018 - 05/2002
4	Hemorrhage 01/2013 - 05/2002
4	Arthritis (Polyarthritis) 01/2007 - 08/2003
3	Hyperplasia 08/2019 - 08/2007
3	Peritonitis 02/2013 - 09/2003
3	Pulmonary Emphysema 11/2010 - 03/2010
3	Pulmonary Edema 09/2006 - 12/2002
2	COVID-19 01/2021 - 12/2020
2	Disease Progression 01/2020 - 03/2010
2	Chronic Obstructive Pulmonary Disease (COPD) 10/2017 - 07/2005
2	Fibrosis (Cirrhosis) 01/2015 - 03/2011
2	Skin Diseases (Skin Disease) 02/2014 - 03/2009
2	Colitis 05/2013 - 08/2004
2	Emphysema 11/2010 - 03/2010

Drug/Important Bio-Agent (IBA)

42	CytokinesIBA 01/2021 - 01/2002
31	1-(2-(dodecyloxy)ethyl)pyrrolidine hydrochloride (DEP)IBA 02/2013 - 04/2002
30	Vehicle Emissions (Emissions, Vehicle)IBA 08/2021 - 04/2002
25	AllergensIBA 01/2022 - 01/2002
25	LipopolysaccharidesIBA 01/2017 - 12/2002
20	Particulate MatterIBA 01/2022 - 09/2006
19	SandIBA 07/2017 - 11/2005
16	ChemokinesIBA 01/2019 - 05/2002
14	OvalbuminIBA 01/2016 - 07/2002
14	EndotoxinsIBA 02/2011 - 05/2002
13	AntigensIBA 01/2014 - 12/2002
12	Interleukin-6 (Interleukin 6)IBA 01/2021 - 10/2003
10	Immunoglobulin G (IgG)IBA 01/2019 - 01/2002
9	Diethylhexyl Phthalate (DEHP)IBA 10/2021 - 08/2006
9	Organic Chemicals (Chemicals, Organic)IBA 07/2017 - 11/2004
8	Immunoglobulins (Immunoglobulin)IBA 02/2014 - 07/2002
8	Proteins (Proteins, Gene)FDA Link 11/2010 - 04/2002
7	InterleukinsIBA 01/2021 - 06/2004
7	Interleukin-5 (Interleukin 5)IBA 11/2020 - 01/2002
7	phthalic acid (phthalate)IBA 07/2017 - 08/2006
7	Chemotactic FactorsIBA 02/2013 - 04/2004
7	urinastatin (MR 20)IBA 04/2010 - 03/2005
6	Immunoglobulin E (IgE)IBA 01/2019 - 01/2002
6	MetallothioneinIBA 05/2013 - 01/2005
6	Serine Proteinase Inhibitors (Serine Protease Inhibitors)IBA 04/2010 - 03/2005
5	Biomarkers (Surrogate Marker)IBA 10/2019 - 04/2002
4	CarbonIBA 09/2017 - 09/2006
4	GlucansIBA 04/2016 - 07/2005
4	Interleukin-13IBA 01/2015 - 08/2005
4	SootIBA 04/2011 - 09/2006
4	Pharmaceutical PreparationsIBA 04/2010 - 03/2005
4	Rosmarinic AcidIBA 07/2006 - 04/2003
3	Messenger RNA (mRNA)IBA 01/2022 - 01/2019
3	Benzo(a)pyreneIBA 12/2021 - 11/2016
3	bisphenol AIBA 01/2019 - 01/2016
3	PlasticizersIBA 07/2017 - 05/2009
3	Environmental Pollutants (Pollutants, Environmental)IBA 07/2017 - 05/2002
3	Toll-Like Receptors (Toll-Like Receptor)IBA 01/2017 - 01/2007
3	Reactive Oxygen Species (Oxygen Radicals)IBA 03/2014 - 04/2002
3	Pancreatic Elastase (Elastase)IBA 04/2011 - 03/2010
3	Carbon Nanotubes (Carbon Nanotube)IBA 04/2010 - 12/2008
3	Interleukin-1beta (Interleukin 1 beta)IBA 03/2010 - 01/2004
3	AntioxidantsIBA 10/2009 - 12/2002
3	Vitamin E FDA LinkGeneric 10/2004 - 12/2002
2	titanium dioxide (Titania)FDA Link 12/2021 - 03/2009
2	Biological ProductsIBA 12/2021 - 11/2010
2	CholesterolIBA 01/2021 - 04/2004
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2021 - 07/2003
2	Air Pollutants (Pollutants, Air)IBA 01/2021 - 07/2017
2	Protease Inhibitors (Protease Inhibitor)IBA 12/2020 - 01/2020
2	Silicon Dioxide (Silica)FDA LinkGeneric 08/2019 - 01/2016
2	Glucose (Dextrose)FDA LinkGeneric 01/2019 - 03/2014
2	Drinking WaterIBA 01/2019 - 08/2004
2	EstersIBA 07/2017 - 05/2009
2	quinone (benzoquinone)IBA 06/2017 - 01/2005
2	ElementsIBA 12/2016 - 04/2016
2	LigandsIBA 04/2016 - 03/2011
2	LipidsIBA 03/2014 - 12/2012
2	diisononyl phthalateIBA 02/2014 - 04/2010
2	OzoneIBA 12/2012 - 12/2008
2	PeroxiredoxinsIBA 12/2012 - 10/2009
2	Therapeutic UsesIBA 06/2012 - 05/2011
2	InflammasomesIBA 01/2012 - 10/2010
2	Methacholine Chloride (Methacholine)FDA Link 11/2010 - 03/2010
2	Cholinergic Agents (Cholinergics)IBA 11/2010 - 03/2010
2	Alkaline PhosphataseIBA 11/2010 - 03/2010
2	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 11/2010 - 03/2010

Therapy/Procedure

2	Aftercare (After-Treatment) 01/2015 - 12/2008